Patiromer Dosage Guide + Max Dose, Adjustments - Drugs.com (2024)

Medically reviewed by Drugs.com. Last updated on Apr 24, 2023.

Applies to the following strengths: 8.4 g; 16.8 g; 25.2 g

Usual Adult Dose for Hyperkalemia

Initial dose: 8.4 g orally once a day

• Monitor serum potassium level and adjust dose in 8.4 mg increments at 1-week intervals based on serum potassium level and desired target range

Maintenance dose: 8.4 to 25.2 mg/day
Maximum dose 25.2 g/day

Comments:

• This drug should not be used as an emergency treatment for life-threatening hyperkalemia because of its delayed onset of action.
• This drug should be administered at least 3 hours before or 3 hours after other oral medications.

Use: For the treatment of hyperkalemia.

Renal Dose Adjustments

No dosing adjustments recommended

Liver Dose Adjustments

No dosing adjustments recommended

Precautions

CONTRAINDICATIONS:

• Hypersensitivity to the active component or any of the ingredients

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• Take orally once a day
• Do not take in its dry form; do not heat in microwave or add to heated foods or liquids
• Prepare each dose immediately prior to administration
• Separate administration of this drug by 3 hours (before or after) from other drugs

Storage requirements:

• Store in the refrigerator at 2C to 8C (36F to 46F).
• Use within 3 months if stored at room temperature (25C [77F])
• Avoid exposure to heat above 40C (104F).

Reconstitution/preparation techniques:
Prepare each dose immediately prior to administration following the steps below:

• Measure 30 mL of water; pour half of the water into a glass and add prescribed packet(s) and stir; add remaining water and stir thoroughly; the powder will not dissolve, and the mixture will look cloudy
• Additional water may be added as desired; apple juice or cranberry juice may be used instead of water
• Consume immediately, if powder remains in the glass, add more water, stir, and drink immediately, repeating as needed to ensure the entire dose is administered

General:

• In clinical trials 93% of patients had chronic kidney disease; no special dosing adjustments are needed for patients with renal impairment.

Monitoring:

• Monitor potassium levels
• Monitor magnesium levels

Patient advice:

• Patients should be instructed on proper preparation of this drug; they should understand that this drug should not be heated (e.g., microwaved) or added to heated foods or liquids and should not be taken in its dry form.
• Patients should be instructed to adhere to their prescribed diets.
• Patients taking other oral medications should separate the dosing of this drug by at least 3 hours (before or after).

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circ*mstances.

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